Locksmiths can often open safes, but the ability to do so depends on several factors, including the type of safe, the locking mechanism, the level of security, and the skills and tools of the locksmith. Here are some considerations:
1.   Type of Safe: There are different types of safes, such as combination safes, key safes, electronic safes, and biometric safes. Each type may require a different approach to opening.
2.   Locking Mechanism: The locking mechanism inside the safe also plays a crucial role. Some safes have traditional mechanical combination locks, while others use electronic or digital locks. The locksmith's expertise in dealing with specific types of locks is essential.